Tucson is one of the oldest continually inhabited cities in the United States, so there is a lot of ground to explore in this desert metropolis.
Saguaro National Park, which flanks the city to the east and west, is home to North America's largest cacti, the iconic giant saguaro. These plants are only found in parts of Arizona and California. You'll get an eyeful at Saguaro National Park, which preserves over 1.6 million of these majestic giants.
For more desert beauty, make sure to pay a visit to the Arizona-Sonora Desert Museum, a 21-acre living museum that is part botanical garden and part wildlife zoo. You'll want to set aside several hours to explore the trails and exhibitions and this unique desert museum.
Explore Tucson's Spanish and Native American heritage at Mission San Xavier del Bac, founded in 1692 by the Jesuit missionary Eusebio Francisco Kino.
If you have time for a day trip, the historic village of Tubac (roughly 50 miles south of Tucson) is the perfect place to pick up authentic Southwestern and Mexican arts and crafts.
Tombstone, located about 70 miles southeast of Tucson, is another great sightseeing opportunity. Walk the streets of "the town too tough to die," including the historic Birdcage Theatre, Boothill Graveyard, and of course, the site of the famous Gunfight at the O.K. Corral.
Back in Tucson, be sure to check out the Pima Air and Space Museum, one of the largest aerospace museums in the world.