Featuring the largest and longest-running improv troupe in San Francisco, this award-winning comedy club's Fort Mason location is a must-visit for anyone seeking a hysterical escape from the everyday. Make sure to bring a tissue, and ladies, break out the waterproof mascara, because once the superbly talented comedians hit the stage, you'll be crying with uncontrollable laughter. The sidesplitting, interactive shows are always 100% unique and include rapid-fire competitions, Shakespeare remixes and wacky murder mysteries. And the Fort Mason Center is a large and comfortable space, located right on the water with the nearby Marina neighborhood to cover all your restaurant, bar, and late-night needs.