Readers of 10Best and USA TODAY chose their top Girls' Trip destinations earlier this year, and every winning destination promises plenty of fun for gals.
Santa Fe won the top spot in our Readers Choice poll – there may be no better place on the planet for a girls’ trip, given the number of excellent spas, the natural beauty, and the chance to browse through dozens of art galleries. Take mom for a Jeep tour of the mountains between Santa Fe and Albuquerque, followed by a visit to Ten Thousand Waves for a spa experience extraordinaire.
Charleston, S.C.'s historic City Market, is where vendors have set up shop every day for over 200 years – and you can snag a sweet grass basket as a souvenir. After a day of shopping, pop into Lulu’s Chocolate Bar for a sinful treat – the signature Lulutini (a chocolate martini) and dessert.
A summer meal at La Taverna, Castello Banfi's restaurant. — Photo courtesy of Castello Banfi Tuscany is ground zero for some of Italy's best wineries, and a stay at Il Borgo, the hotel attached to Castello Banfi takes agri-tourism to its most luxurious level. The historic castle-like hotel and winery offers tastings and tours as well as cooking classes, yoga and more for its fortunate guests.
Charming Carmel-by-the-Sea is jam-packed with wineries, boutiques, a gastronomic delights - all set in incredibly California-cool architecture. While away the afternoon by taking Mom on the Carmel Wine Walk through a dozen tasting rooms.
Carmel's Wine Walk allows you to stroll through the charming seaside village, sipping as you go. — Photo courtesy of Carmel By-The-Sea
Nashville's Frist Center for the Visual Arts is a treat, both for its art deco soul (it is the former downtown post office) and its ever-changing collection of exhibits. The Frist has no permanent collection, so its curated traveling exhibits bring together some of the world's finest art in the most interesting combinations.
There are few towns more inherently charming than Savannah, with its pretty squares and Antebellum architecture. When you've finished taking in the squares via a carriage ride, Stay at the hip new Andaz Hotel, and indulge yourself with some downtime at the rooftop pool. 
The rooftop pool at the Andaz beckons on a humid Savannah day. — Photo courtesy of Andaz Hotel, Savannah
In Tucson, there's no better spot for rejuvenation of the body & soul than the stunning destination spa Miraval. The resort / wellness center is holistic in its approach, with a focus on sustainability and green initiatives.
Don't let everything that happens in Vegas stay there - instead, take home great memories of your time with friends by finding that perfect piece of art at The Arts Factory, a collection of artists workshops and retail shops located in Sin City's arts district.
New York is all about fashion, so what better way to spoil yourselves with a tour of the city's Garment District? Schedule a walking tour of the district with district expert Mike Kaback of Mike's NYC Tours, the most fashion-forward ladies will discover the inside scoop about where and how to shop in the district. Don't forget to bring cash, just in case you find the chance to buy.
Having grown up in Chicago, it's hard to pick just a couple of things to do with your gal pals. But our favorite girlie activity was lunch - and the Zodiac restaurant at Neiman Marcus on Michigan Avenue is still our go-to spot. Now, however, we like to start off the day with a massage at the Spa at the Trump International Hotel & Tower.